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KMID : 1189420040170030008
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2004 Volume.17 No. 3 p.8 ~ p.17
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The Anti-Inflammatory Effects of NeiShuHuangLianTang In Experi-mental Animals
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Ahn Jong-Hyun
Sim Sung-Yong
Kim Kyung-Jun
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Abstract
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Objective: Under recognition of the similarity between carbuncle in Oriental medicine and inflammatory disease, NeiShuHuangLianJang(N.H.) has been used as an antiphlogistic agent. The present reports shows the anti-inflammatory effects of N.H.
Method: Experimental animals made use of 4-5 weeks age(weight 20-25g) ICR(male)mouse. They were farmed individually in a temperature(22±0.5Ο) and light(06:00 to 18:00 h) controlled room with free access to water and food. The N.H.(1.0g／kg, 3.0g／kg) extracted from NeiShuHuangLianTang were administered intragastrically prior to LPS I.P injection. we measured WBC count, IL-6 level in plasma and TNF-α level in plasma.
Result : 1. N.H. suppressed inflammatory reaction induced by LPS. 2. N.H. suppressed WBC count in inflammatory reaction induced by LPS. 3. N.H. suppressed 1L-6 level in inflammatory reaction induced by LPS. According to above experiments, N.H. was improved its suppression effect against the inflammatory reaction through WBC count and IL-6 level. So N.H. which is used for the inflammatory disease(carbuncle) in Oriental Medicine is assumed to have a curative effects against this disease by controlling WBC count and IL-6 level in plasma.
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KEYWORD
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NeishuHuangLianTang , Carbuncle , Inflammatory , Anti-inflammatory , IL-6 , TNF-a , LPS
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